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As we reach the limit of Moore’s Law, researchers are exploring different paradigms to achieve unprecedented performance. Approximate Computing (AC), which relies on the ability of applications to tolerate some error in the results to trade-off accuracy for performance, has shown significant promise. Despite the success of AC in domains such as Machine Learning, its acceptance in High-Performance Computing (HPC) is limited due to its stringent requirement of accuracy. We need tools and techniques to identify regions of the code that are amenable to approximations and their impact on the application output quality so as to guide developers to employ selective approximation. To this end, we propose CHEF-FP, a flexible, scalable, and easy-to-use source-code transformation tool based on Automatic Differentiation (AD) for analysing approximation errors in HPC applications. CHEF-FP uses Clad, an efficient AD tool built as a plugin to the Clang compiler and based on the LLVM compiler infrastructure, as a backend and utilizes its AD abilities to evaluate approximation errors in C++ code. CHEF-FP works at the source level by injecting error estimation code into the generated adjoints. This enables the error-estimation code to undergo compiler optimizations resulting in improved analysis time and reduced memory usage. We also provide theoretical and architectural augmentations to source code transformation-based AD tools to perform FP error analysis. In this paper, we primarily focus on analyzing errors introduced by mixed-precision AC techniques, the most popular approximate technique in HPC. We also show the applicability of our tool in estimating other kinds of errors by evaluating our tool on codes that use approximate functions. Moreover, we demonstrate the speedups achieved by CHEF-FP during analysis time as compared to the existing state-of-the-art tool as a result of its ability to generate and insert approximation error estimate code directly into the derivative source. The generated code also becomes a candidate for better compiler optimizations contributing to lesser runtime performance overhead. 

The Gemini Planet Imager (GPI) is a high-contrast imaging instrument designed to directly detect and char- acterise young, Jupiter-mass exoplanets. After six years of operation at the Gemini South Telescope in Chile, the instrument is being upgraded and moved to the Gemini North Telescope in Hawaii as GPI 2.0. Several improvements have been made to the adaptive optics (AO) system as part of this upgrade. This includes re- placing the current Shack-Hartmann wavefront sensor with a pyramid wavefront sensor (PWFS) and a custom EMCCD. These changes will increase GPI’s sky coverage by accessing fainter targets, improving corrections on fainter stars and allowing faster and ultra-low latency operations on brighter targets. The PWFS subsystem was independently built and tested to verify its performance before being integrated into the GPI 2.0 instrument. This paper will present the pre-integration performance test results, including pupil image quality, throughput and linearity without modulation. 

Abstract Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.